Post-COVID-19 pandemic organ donation activities in Germany: a multicenter retrospective analysis.

Publication date: Dec 15, 2023

The COVID-19 pandemic had a negative impact on the number of solid organ transplantations. After a global decline of 16% in 2020, their numbers subsequently returned to pre-pandemic levels. In contrast, numbers in Germany remained almost constant in 2020 and 2021 but fell by 6. 9% in 2022. The reasons for this divergent development are unknown. The number of deceased with a severe brain damage, potential and utilized donors after braindeath and the intensive care unit treatment capacity were retrospectively compared for the years 2022 and 2021 at five university hospitals in North Rhine-Westphalia, Germany. Reasons for a donation not utilized were reviewed. To enable a comparison of the results with the whole of Germany and the pre-pandemic period, numbers of potential and utilized donors were extracted from official organ donation activity reports of all harvesting hospitals in Germany for the years 2019-2022. The numbers of deceased with a severe brain damage (-10%), potential (-9%), and utilized donors after braindeath (-44%), and intensive care unit treatment capacities (-7. 2%) were significantly lower in 2022 than 2021. A COVID-19 infection was a rarer (-79%), but donor instability (+44%) a more frequent reason against donation in 2022, whereas preserved brain stem reflexes remained the most frequent reason in both years (54%). Overall numbers of potential and utilized donations in Germany were lower in 2022 than in the pre-pandemic period, but this was mainly due to lower numbers in hospitals of lower care. The number of potential donors in all university hospitals were higher in 2022 but utilized donations still lower than in 2019. The decrease in potential and utilized donations was a result of reduced intensive care unit treatment capacities and a lower conversion rate at the five university hospitals. A COVID-19 infection did not play a role in 2022. These results indicate that ICU treatment capacities must be restored to increase donations. The lower number of potential donors and the even lower conversion rate in 2022 throughout Germany show that restructuring the organ procurement process in Germany needs to be discussed to increase the number of donations.

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Concepts Keywords
Germany brain death
Hospitals conversion rate
Organ COVID-19
Rarer COVID-19
Germany
Hospitals, University
Humans
ICU capacity
organ donation
organ procurement
Organ Transplantation
Pandemics
Retrospective Studies

Semantics

Type Source Name
disease MESH COVID-19 pandemic
disease VO organ
disease MESH infection
disease IDO process
drug DRUGBANK Ribostamycin
pathway REACTOME Reproduction
disease MESH brain death
disease MESH emergency
disease MESH uncertainty
drug DRUGBANK Etoperidone
disease VO organization
disease VO report
disease MESH stroke
disease VO time
disease MESH aneurysmal subarachnoid hemorrhage
disease MESH acute ischemic stroke
disease MESH death
disease MESH contraindication
disease MESH malignancy
disease VO monthly
disease VO population
disease IDO algorithm
disease VO company
disease VO ANOVA

Original Article

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