COVID-19 outbreak among employees of a German hospital: risk factor analysis based on a follow-up questionnaire and seroprevalence.

Publication date: Mar 15, 2024

The Co-FriSero study describes a COVID-19 outbreak at the Friedrichroda hospital in Thuringia, Germany, with 185 beds and 404 employees, at the onset of the pandemic between March 30th, 2020, and April 13th, 2020. This study aimed to analyze potential sources of SARS-CoV-2 transmission amongst hospital employees. After the outbreak, a comprehensive follow-up was conducted through a questionnaire and a seroprevalence study using two different immunoassays for IgG detection and a third for discordant results. PCR screenings confirmed SARS-CoV-2 infection in 25 of 229 employees, with an additional 7 detected through serology. Statistical analysis indicated that direct patient contact, exposure to high flow ventilation in non-isolated rooms, direct contact with colleagues, shared use of recreational rooms, and carpooling were associated with an increased infection risk. Conversely, contact with family and friends, public transportation, public events, and use of locker rooms were not associated with infection. Male gender showed a lower infection likelihood, independent of age and other risk factors. This study highlights the role of direct patient care and internal staff interactions in the spread of SARS-CoV-2 in the hospital setting. It suggests that non-traditional transmission routes like carpooling require consideration in pandemic preparedness.

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Concepts Keywords
Carpooling COVID-19
Discordant Health care worker
Germany Nosocomial transmission
Immunoassays Outbreak report
Seroepidemiologic studies


Type Source Name
disease MESH COVID-19
pathway REACTOME SARS-CoV-2 Infection
disease MESH infection
drug DRUGBANK Etoperidone
disease MESH pneumonia
disease MESH complications
disease VO protocol
disease MESH causes
disease VO effectiveness
disease IDO facility
disease MESH emergency
disease IDO blood
disease MESH education level
disease MESH sore throat
disease IDO assay
disease VO USA
disease VO time
drug DRUGBANK Methionine
drug DRUGBANK Pentaerythritol tetranitrate
disease IDO symptom
drug DRUGBANK Coenzyme M
drug DRUGBANK Medical air
disease VO age
disease MESH asymptomatic infections
disease VO report
disease VO population
drug DRUGBANK Cefalotin
drug DRUGBANK (S)-Des-Me-Ampa
disease VO Viruses
disease MESH death

Original Article

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