Catalysing global surgery: a meta-research study on factors affecting surgical research collaborations with Africa.

Catalysing global surgery: a meta-research study on factors affecting surgical research collaborations with Africa.

Publication date: Mar 18, 2024

In December 2019, the COVID-19 pandemic highlighted the urgent need for rapid collaboration, research, and interventions. International research collaborations foster more significant responses to rapid global changes by enabling international, multicentre research, decreasing biases, and increasing study validity while reducing overall research time and costs. However, there has been low uptake of collaborative research by African institutions and individuals. To systematically review facilitating factors and challenges to collaborative surgical research studies conducted in Africa. A meta-research review using PubMed(R)/MEDLINE and Embase on surgical collaboration in Africa from 1st of January 2011 to 31st of September 2021 in accordance to PRISMA guidelines. Surgical studies by collaborative groups involving African authors and sites were included (55 papers). Data on the study period, geographical regions, and research scope, facilitating factors, and challenges were extracted from the studies retrieved from the search. Most of the collaborations in Africa occurred with European institutions (76%). Of the 54 African countries, 63% (34/54) participated in surgical collaborations. The highest collaboration frequency occurred in South Africa (11%) and Nigeria (8%). However, most publications originated from Eastern Africa (43%). Leveraging synergies between high- and low- to middle-income countries (LMICs), well-defined structures, and secure data platforms facilitated collaboration. However, the underrepresentation of collaborators from LMICs was a significant challenge. Available literature provides critical insights into the facilitating factors and challenges of research collaboration with Africa. However, there is a need for a detailed prospective study to explore the themes highlighted further. PROSPERO 2022 CRD42022352115 .

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Concepts Keywords
Crd42022352115 Africa
December Collaborations
Global COVID-19
September Research
Surgery Surgery


Type Source Name
disease MESH Congenital heart defects
disease VO vaccination
disease VO Rotavirus
disease VO URE
disease MESH encephalopathy
disease MESH emergency
disease MESH bleeding
disease MESH Glaucoma
disease MESH infection
drug DRUGBANK Tranexamic acid
disease MESH Neural Tube Defect
disease MESH open spina bifida
disease MESH retinal detachments
disease MESH macular hole
drug DRUGBANK Chlorhexidine
disease VO effectiveness
disease MESH obesity
disease IDO production
disease MESH Severe Acute Respiratory Syndrome
drug DRUGBANK Aspartame
disease IDO host
disease VO Equity
drug DRUGBANK Esomeprazole
disease IDO quality
disease IDO country
disease VO document
disease MESH Intussusception
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Indoleacetic acid
disease MESH hepatocellular carcinoma
pathway KEGG Hepatocellular carcinoma
disease VO cancer
disease MESH Tumors
disease IDO process
drug DRUGBANK Methionine
disease VO protocol
drug DRUGBANK Spinosad
disease VO USA
disease VO volume
disease VO population
drug DRUGBANK Trestolone
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Coenzyme M
pathway REACTOME Reproduction
disease VO frequency
disease VO time
disease MESH COVID-19 pandemic

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