COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect?

COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect?

Publication date: Mar 19, 2024

A rising number of patient cases point to a probable link between SARS-CoV-2 infection and Parkinson’s disease (PD), yet the mechanisms by which SARS-CoV-2 affects the brain and generates neuropsychiatric symptoms in COVID-19 patients remain unknown. Ferroptosis, a distinct iron-dependent non-apoptotic type of cell death characterized by lipid peroxidation and glutathione depletion, a key factor in neurological disorders. Ferroptosis may have a pathogenic role in COVID-19, according to recent findings, however its potential contributions to COVID-19-related PD have not yet been investigated. This review covers potential paths for SARS-CoV-2 infection of the brain. Among these putative processes, ferroptosis may contribute to the etiology of COVID-19-associated PD, potentially providing therapeutic methods.

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Concepts Keywords
Discov Brain
Iron Cov
Neuropsychiatric Covid
Parkinson Death
Pathogenic Disease
Ferroptosis
Infection
Manifestations
Neurological
Parkinson
Pd
Potential
Related
Sars

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Parkinson’s disease
pathway KEGG Ferroptosis
pathway REACTOME SARS-CoV-2 Infection
drug DRUGBANK Iron
disease VO IroN
drug DRUGBANK Glutathione
disease MESH neurological disorders
disease MESH etiology
disease MESH Long Covid

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