Developing CAR-immune cell therapy against SARS-CoV-2: Current status, challenges and prospects.

Developing CAR-immune cell therapy against SARS-CoV-2: Current status, challenges and prospects.

Publication date: Apr 01, 2024

Chimeric antigen receptor (CAR)-immune cell therapy has revolutionized the anti-tumor field, achieving efficient and precise tumor clearance by directly guiding immune cell activity to target tumors. In addition, the use of CAR-immune cells to influence the composition and function of the immune system and ultimately achieve virus clearance and immune system homeostasis has attracted the interest of researchers. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered a global pandemic of coronavirus disease 2019 (COVID-19). To date, the rapidly mutating SARS-CoV-2 continues to challenge existing therapies and has raised public concerns regarding reinfection. In patients with COVID-19, the interaction of SARS-CoV-2 with the immune system influences the course of the disease, and the coexistence of over-activated immune system components, such as macrophages, and severely compromised immune system components, such as natural killer cells, reveals a dysregulated immune system. Dysregulated immune-induced inflammation may impair viral clearance and T-cell responses, causing cytokine storms and ultimately leading to patient death. Here, we summarize the research progress on the use of CAR-immune cells against SARS-CoV-2 infection. Furthermore, we discuss the feasibility, challenges and prospect of CAR-immune cells as a new immune candidate therapy against SARS-CoV-2.

Concepts Keywords
Biochem Coronavirus disease 2019
Car Immunotherapy
Coronavirus
Efficient
Homeostasis

Semantics

Type Source Name
disease IDO cell
disease MESH tumor
disease VO efficient
pathway REACTOME Immune System
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH coronavirus disease 2019
disease MESH reinfection
disease MESH inflammation
disease MESH cytokine storms
disease MESH death

Original Article

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