Risk of COVID-19 in pediatric population and the effects of COVID-19 vaccination: A retrospective cohort study.

Publication date: Mar 22, 2024

Prior studies have demonstrated the adverse effects of upper respiratory infections on the pediatric population, such as increased risk for acute otitis media (AOM). Other studies have noted decreased otitis media complaints during the COVID-19 pandemic. This project aims to identify whether individuals who tested positive for COVID-19 at the Emergency Department (ED) visit had an increased risk of developing severe complications. Additionally, we will study whether vaccination helped decrease following COVID-19 complications. Utilizing the TriNetX database, we obtained de-identified electronic medical records for children under five and 6-10 years old from 2020-2023 in the United States. The study population was propensity-matched for gender, index age, and comorbidities. Complications within eight weeks of the ED visit were compared between COVID-19 vaccinated and unvaccinated children. Risk ratio was used to measure associations between our groups. A p-value less than or equal to 0. 05 was considered significant. After propensity matching, a total of 211,138 children were identified. Within eight weeks after the ED visit, unvaccinated children

Concepts Keywords
Larynx Acute Otitis media
Pandemic COVID-19
Vaccinated COVID-19 pediatric Vaccine
Pediatric ENT


Type Source Name
disease MESH COVID-19
disease VO population
disease VO vaccination
disease MESH upper respiratory infections
disease MESH otitis media
disease MESH Emergency
disease MESH complications
disease VO vaccinated
disease VO unvaccinated
drug DRUGBANK Aspartame
disease MESH Long Covid
disease VO vaccine

Original Article

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