Smartphone-based device for point-of-care diagnostics of pulmonary inflammation using convolutional neural networks (CNNs).

Publication date: Mar 22, 2024

In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a chest CT scan. However, the lack of accessibility to the CT machines in many poor medical centers as well as its expensive service, demands more accessible methods for fast and cheap detection of lung inflammation. Here, we have introduced a novel method for tracing the inflammation and lung involvement in patients with pulmonary inflammation, such as COVID-19, by a simple electrolyte detection in their sputum samples. The presence of the electrolyte in the sputum sample results in the fern-like structures after air-drying. These fern patterns are different in the CT positive and negative cases that are detected by an AI application on a smartphone and using a low-cost and portable mini-microscope. Evaluating 160 patient-derived sputum sample images, this method demonstrated an interesting accuracy of 95%, as confirmed by CT-scan results. This finding suggests that the method has the potential to serve as a promising and reliable approach for recognizing lung inflammatory diseases, such as COVID-19.

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Concepts Keywords
Cnns Based
Ct Covid
Diseases Detected
Reliable Detection
Smartphone Device
Diseases
Electrolyte
Fern
Inflammation
Involvement
Lung
Pulmonary
Scan
Smartphone
Sputum

Semantics

Type Source Name
disease VO device
disease MESH pulmonary inflammation
disease MESH COVID-19
disease MESH inflammation
disease MESH cytokine storm
disease VO LACK
drug DRUGBANK Medical air
disease MESH Long Covid
drug DRUGBANK Coenzyme M
disease MESH Cardiovascular Diseases
disease IDO algorithm
disease VO efficiency
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Gold
disease VO Gap
disease IDO intervention
disease IDO blood
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Sodium Chloride
disease IDO immune response
disease MESH death
drug DRUGBANK Potassium
disease IDO history
drug DRUGBANK Ethanol
disease VO volume
disease VO Pla
disease IDO process
drug DRUGBANK Flunarizine
drug DRUGBANK Saquinavir
pathway REACTOME Translation
disease VO Viruses
drug DRUGBANK Tropicamide
disease MESH acute respiratory distress syndrome
disease MESH hypernatremia
disease MESH hyperkalemia
drug DRUGBANK Tretamine
disease IDO object
disease MESH pulmonary diseases
disease MESH asthma
pathway KEGG Asthma
disease MESH COPD
disease VO effective
disease VO time
drug DRUGBANK Oxygen
disease IDO assay
disease MESH viral pneumonia
drug DRUGBANK N-acetylsulfanilyl chloride
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH infection
disease MESH metastasis
disease VO frequency
disease MESH tumor
pathway KEGG Apoptosis
disease MESH bacterial infections
disease MESH Allergy
disease MESH syndrome

Original Article

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