Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis.

Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis.

Publication date: Mar 28, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurological complications. The variety of symptoms makes it difficult to unravel molecular mechanisms underlying neurological sequalae after coronavirus disease 2019 (COVID-19). Here we show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential. Using cerebral organoids, organotypic culture of human brain explants from individuals without COVID-19 and post-mortem brain samples from individuals with COVID-19, we find that neural cells are permissive to SARS-CoV-2 to a low extent. SARS-CoV-2 induces aberrant presynaptic morphology and increases expression of the synaptic components Bassoon, latrophilin-3 (LPHN3) and fibronectin leucine-rich transmembrane protein-3 (FLRT3). Furthermore, we find that LPHN3-agonist treatment with Stachel partially restored organoid electrical activity and reverted SARS-CoV-2-induced aberrant presynaptic morphology. Finally, we observe accumulation of relatively static virions at LPHN3-FLRT3 synapses, suggesting that local hindrance can contribute to synaptic perturbations. Together, our study provides molecular insights into SARS-CoV-2-brain interactions, which may contribute to COVID-19-related neurological disorders.

Concepts Keywords
Agonist Brain
Bassoon Coronavirus
Coronavirus Cov
Homeostasis Covid
Rich Electrical


Type Source Name
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH infection
disease MESH complications
disease MESH coronavirus disease 2019
drug DRUGBANK L-Leucine
disease MESH neurological disorders

Original Article

(Visited 1 times, 1 visits today)