Role of HLA-G in tumors and upon COVID-19 infection.

Role of HLA-G in tumors and upon COVID-19 infection.

Publication date: Mar 29, 2024

HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research.

Concepts Keywords
Covid HLA-G
Genetic Immune response
Microenvironment Regulation
Tumors Tumor
Viral Virus

Semantics

Type Source Name
disease MESH tumors
disease MESH COVID-19
disease MESH infection
disease MESH viral infections
disease MESH abnormalities
disease VO frequency
disease MESH clinical relevance
disease IDO immune response

Original Article

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