Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023.

Publication date: Mar 08, 2024

To provide updated estimates on SARS-CoV-2 antibody seroprevalence and average antibody titres for Central Europe. In repeat cross-sectional investigations (1 May 2022 to 9 March 2023) involving 28,768 blood donors in the Federal State of Tyrol, Austria (participation rate: 87. 0%), we measured Spike receptor-binding domain (RBD) and Nucleocapsid IgG antibodies (37,065 and 12,645 samples), and estimated monthly seroprevalences and geometric mean titres. Median age of participants was 45. 4 years (range 18-70); 43. 2% were female. Spike RBD IgG antibody seroprevalence was 96. 3% (95% CI: 95. 6-96. 9%) in May 2022, 97. 4% (96. 7-98. 0%) in December 2022, and 97. 9% (96. 4-98. 8%) in March 2023. Among seropositive participants, geometric mean titres increased from 1400 BAU/mL (95% CI: 1333-1471) in May 2022 to 1821 BAU/mL (1717-1932) in December 2022, and dropped to 1559 BAU/mL (1405-1729) by March 2023. Furthermore, titres differed markedly by vaccination status and history of infection, with being the highest in participants with booster vaccination and prior infection. In autumn 2022, Nucleocapsid IgG antibody seroprevalence ranged from 36. 5% (35. 0-38. 1) in September to 39. 2% (37. 2-41. 2) in December 2022. Seroprevalence of SARS-CoV-2 antibodies in blood donors from Tyrol, Austria, was remarkably stable from May 2022 to March 2023. In contrast, average Spike RBD IgG antibody titres peaked in December 2022.

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Concepts Keywords
Austria blood donors
Female COVID-19
Vaccination Nucleocapsid IgG antibodies
SARS-CoV-2 IgG antibodies
seroprevalence
Spike IgG antibodies

Semantics

Type Source Name
disease IDO blood
disease VO monthly
disease VO vaccination
disease IDO history
disease MESH infection
disease MESH COVID 19
disease VO population
disease IDO pathogen
drug DRUGBANK Coenzyme M
disease VO time
disease IDO symptom
disease VO manufacturer
disease MESH sid
disease IDO assay
disease VO vaccinated

Original Article

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