Clinical Manifestations of Infections with the Omicron Sub-Lineages BA.1, BA.2, and BA.5: A Retrospective Follow-Up Analysis of Public Health Data from Mecklenburg-Western Pomerania, Germany.

Clinical Manifestations of Infections with the Omicron Sub-Lineages BA.1, BA.2, and BA.5: A Retrospective Follow-Up Analysis of Public Health Data from Mecklenburg-Western Pomerania, Germany.

Publication date: Mar 15, 2024

The Omicron variants BA. 1, BA. 2, and BA. 5 caused several waves of SARS-CoV-2 in Germany in 2022. In this comparative study, public health data on SARS-CoV-2 infections from Mecklenburg-Western Pomerania, Germany, between January and October 2022 were examined retrospectively using Pearson’s chi-squared tests and Fisher’s exact tests for testing for statistical significance. Compared to BA. 5 infections, BA. 1 and BA. 2 infections affected younger individuals aged up to 19 years significantly more often, whereas BA. 5 infections occurred significantly more frequently in patients between 40 and 59 years of age when compared to BA. 1 and BA. 2. Infections with all three variants predominantly caused flu-like symptoms; nevertheless, there were significant differences between the reported symptoms of BA. 1, BA. 2, and BA. 5 infections. Especially, the symptoms of ‘fever’, ‘severe feeling of sickness’, ‘loss of taste’, and ‘loss of smell’ were significantly more often present in patients with BA. 5 infections compared to BA. 1 and BA. 2 cases. Additionally, BA. 2 and BA. 5 cases reported significantly more often the symptoms of ‘runny nose’ and ‘cough’ than BA. 1-infected cases. Our findings indicate remarkable differences in the clinical presentations among the sub-lineages, especially in BA. 5 infections. Furthermore, the study demonstrates a powerful tool to link epidemiological data with genetic data in order to investigate their potential impact on public health.

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Concepts Keywords
Epidemiology Aged
Germany BA.1
October BA.2
Powerful BA.5
Viruses COVID-19
COVID-19
Follow-Up Studies
Germany
Germany
Humans
Mecklenburg-Western Pomerania
Omicron
pandemic
Public Health
Retrospective Studies
SARS-CoV-2
surveillance
symptoms

Semantics

Type Source Name
disease MESH Infections
disease MESH SARS-CoV-2 infections
disease VO nose
disease IDO infection
disease VO organization
disease MESH Severe Acute Respiratory Syndrome
disease MESH emergency
disease MESH mutation rate
drug DRUGBANK Coenzyme M
disease VO time
disease VO report
disease VO USA
drug DRUGBANK Pentaerythritol tetranitrate
disease VO vaccination
disease VO vaccinated
disease MESH re infection
disease VO frequency

Original Article

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