Cistus incanus: a natural source of antimicrobial metabolites.

Cistus incanus: a natural source of antimicrobial metabolites.

Publication date: Apr 01, 2024

The discovery of natural molecules with antimicrobial properties has become an urgent need for the global treatment of bacterium and virus infections. Cistus incanus, a Mediterranean shrub species, represents a valuable source of phytochemicals with an interesting wide-spectrum antimicrobial potential. In this study, we analysed the spectrum of molecules composing a commercial hydroalcoholic extract of C. incanus finding ellagitannins as the most abundant. The effect of the extract and its main constituents (gallic acid, ellagic acid and punicalin) was assessed as co-treatment during viral (HSV-1, HCoV-229E, SARS-CoV-2) and bacterial infection (Staphylococcus aureus and Escherichia coli) of cells and as pre-treatment before virus infections. The results indicated a remarkable antiviral activity of punicalin against SARS-CoV-2 by pre-treating both the viral and the host cells, and a major sensitivity of S. aureus to the C. incanus extract compared to E. coli. The present study highlights broad antimicrobial potential of C. incanus extract.

Concepts Keywords
Antimicrobial Cistus incanus
Mediterranean ellagitannins
Staphylococcus UHPLC-HRMS/MS


Type Source Name
disease MESH virus infections
drug DRUGBANK Ellagic Acid
disease MESH bacterial infection
disease IDO host

Original Article

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