Comparative evaluation of tocilizumab and itolizumab for treatment of severe COVID-19 in India: a retrospective cohort study.

Comparative evaluation of tocilizumab and itolizumab for treatment of severe COVID-19 in India: a retrospective cohort study.

Publication date: Apr 01, 2024

Itolizumab downregulates the synthesis of proinflammatory cytokines and adhesion molecules by inhibiting CD6 leading to lower levels of interferon-γ, interleukin-6, and tumor necrotic factor-α and reduced T-cell infiltration at inflammatory sites. This study aims to compare the effects of tocilizumab and itolizumab in the management of severe coronavirus disease 2019 (COVID-19). The study population was adults (>18 years) with severe COVID-19 pneumonia admitted to the intensive care unit receiving either tocilizumab or itolizumab during their stay. The primary outcome was clinical improvement (CI), defined as a two-point reduction on a seven-point ordinal scale in the status of the patient from initiating the drug or live discharge. The secondary outcomes were time until CI, improvement in PO2/FiO2 ratio, best PO2/FiO2 ratio, need for mechanical ventilation after administration of study drugs, time to discharge, and survival days. Of the 126 patients included in the study, 92 received tocilizumab and 34 received itolizumab. CI was seen in 46. 7% and 61. 7% of the patients in the tocilizumab and itolizumab groups, respectively and was not statistically significant (P=0. 134). The PO2/FiO2 ratio was significantly better with itolizumab compared to tocilizumab (median [interquartile range]: 315 [200-380] vs. 250 [150-350], P=0. 043). The incidence of serious adverse events due to the study drugs was significantly higher with itolizumab compared to tocilizumab (14. 7% vs. 3. 3%, P=0. 032). The CI with itolizumab is similar to tocilizumab. Better oxygenation can be achieved with itolizumab and it can be a substitute for tocilizumab in managing severe COVID-19.

Concepts Keywords
Covid COVID-19
Cytokines itolizumab
Live management
Pneumonia tocilizumab

Semantics

Type Source Name
drug DRUGBANK Tocilizumab
disease MESH COVID-19
disease MESH tumor
disease IDO cell
disease VO population
disease MESH pneumonia
disease VO time
drug DRUGBANK Tropicamide

Original Article

(Visited 1 times, 1 visits today)