Global trends in chronic kidney disease-related mortality: a systematic review protocol.

Publication date: Apr 03, 2024

In recent decades, all-cause mortality has increased among individuals with chronic kidney disease (CKD), influenced by factors such as aetiology, standards of care and access to kidney replacement therapies (dialysis and transplantation). The recent COVID-19 pandemic also affected mortality over the past few years. Here, we outline the protocol for a systematic review to investigate global temporal trends in all-cause mortality among patients with CKD at any stage from 1990 to current. We also aim to assess temporal trends in the mortality rate associated with the COVID-19 pandemic. We will conduct a systematic review of studies reporting mortality for patients with CKD following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search electronic databases, national and multiregional kidney registries and grey literature to identify observational studies that reported on mortality associated with any cause for patients with CKD of all ages with any stage of the disease. We will collect data between April and August 2023 to include all studies published from 1990 to August 2023. There will be no language restriction, and clinical trials will be excluded. Primary outcome will be temporal trends in CKD-related mortality. Secondary outcomes include assessing mortality differences before and during the COVID-19 pandemic, exploring causes of death and examining trends across CKD stages, country classifications, income levels and demographics. A systematic review will analyse existing data from previously published studies and have no direct involvement with patient data. Thus, ethical approval is not required. Our findings will be published in an open-access peer-reviewed journal and presented at scientific conferences. CRD42023416084.

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Concepts Keywords
August Chronic renal failure
Crd42023416084 Dialysis
Kidney Mortality
Pandemic Renal transplantation
Stage Systematic Review


Type Source Name
disease MESH chronic kidney disease
disease VO protocol
disease MESH COVID-19 pandemic
disease MESH causes of death
disease IDO country
disease MESH death
disease VO effectiveness
drug DRUGBANK Coenzyme M
disease VO USA
disease MESH acute kidney injury
disease MESH complications
disease MESH kidney failure
disease MESH infection
disease MESH morbidity
disease VO population
disease MESH Kidney Disease
pathway REACTOME Translation
disease MESH critical illness
drug DRUGBANK Trestolone
disease IDO process
disease MESH Chronic renal failure

Original Article

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