Unlocking cancer vaccine potential: What are the key factors?

Unlocking cancer vaccine potential: What are the key factors?

Publication date: Dec 31, 2024

Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in a small proportion of patients and come at a high cost. Cancer vaccines may offer a solution to these challenges, but they have been mired by poor results in past decades. Greater understanding of tumor biology, coupled with the success of vaccine technologies during the COVID-19 pandemic, has reinvigorated cancer vaccine development. With the first signs of efficacy being reported, cancer vaccines may be beginning to fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous cancer vaccine clinical development and contemporary knowledge of tumor immunology, we ask: who are the ‘right’ patients, what are the ‘right’ targets, and which are the ‘right’ modalities to maximize the chances of cancer vaccine success?

Concepts Keywords
Decades cancer antigen
Poor Cancer vaccine
Reinvigorated clinical development
Tumors immunotherapy
Vaccines oncology
solid tumors
tumor biology

Semantics

Type Source Name
disease VO cancer vaccine
disease MESH Cancer
disease MESH lifestyle factors
drug DRUGBANK Spinosad
disease VO vaccine
disease MESH COVID-19 pandemic
disease MESH infectious diseases

Original Article

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