Publication date: Jun 14, 2024
Immunological memory to vaccination and viral infection involves coordinated action of B and T-cells, thus integrated analysis of these two components is critical for understanding their contributions to protection against breakthrough infections (BI). We investigated cellular and humoral immune responses to SARS-CoV-2 infection and/or COVID-19 vaccination in participants from the Avon Longitudinal Study of Parents and Children (ALSPAC). The magnitude of antibody and T-cell responses following the second vaccine dose was associated with protection against BI in participants with a history of SARS-CoV-2 infection (cases), but not in infection-naive controls. Youdens index thresholds for protection against BI were calculated for all immune measures. Anti-Spike IgG (>666.4 BAU/mL) and anti-nucleocapsid N pan Ig (>0.1332 BAU/mL) thresholds combined were 100% sensitive and 83% specific for cases without BI over 8-months follow-up. Collectively these results point to the superior protective effect of hybrid immunity and have implications for the design of next-generation COVID-19 vaccines.
| Concepts | Keywords |
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| 1000g | Anti |
| June | Bristol |
| Receptionists | Cov |
| Vaccines | Covid |
| Zombie | Figure |
| Igg | |
| Infection | |
| Medrxiv | |
| Participants | |
| Preprint | |
| Protection | |
| Sars | |
| Serum | |
| Specific | |
| Vaccination |