Publication date: May 01, 2024
Secondary organizing pneumonia (SOP) as a sequela to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually has a prolonged benign course with a good response to corticosteroids. We present a case series of three patients who developed rapid progression to organizing pneumonia, after initial presentation with SARS-CoV-2. Imaging revealed rapid interval progression of bilateral subpleural ground glass opacities, and lung biopsy showed dense fibroblastic plugs within the alveoli. Two patients were steroid-responsive, and one patient succumbed to his illness despite maximal therapy. We postulate that B-cell depletion and immunosuppression may cause rapid progression to SOP, as all three patients were immunosuppressed and on chronic rituximab therapy.
| Concepts | Keywords |
|---|---|
| Biopsy | covid-19 |
| Fibroblastic | immunosuppression |
| Immunosuppression | lung |
| Maximal | rituximab |
| Pneumonia | secondary organizing pneumonia |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Secondary Organizing Pneumonia |
| disease | IDO | immunosuppression |
| drug | DRUGBANK | Rituximab |
| disease | VO | Severe acute respiratory syndrome coronavirus 2 |
| disease | IDO | cell |
| disease | MESH | covid-19 |