Publication date: Jun 24, 2024
Highly pathogenic coronaviruses have caused significant outbreaks in humans and animals, posing a serious threat to public health. The rapid global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in millions of infections and deaths. However, the mechanisms through which coronaviruses evade a host’s antiviral immune system are not well understood. Liquid-liquid phase separation (LLPS) is a recently discovered mechanism that can selectively isolate cellular components to regulate biological processes, including host antiviral innate immune signal transduction pathways. This review focuses on the mechanism of coronavirus-induced LLPS and strategies for utilizing LLPS to evade the host antiviral innate immune response, along with potential antiviral therapeutic drugs and methods. It aims to provide a more comprehensive understanding and novel insights for researchers studying LLPS induced by pandemic viruses.
Open Access PDF
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Coronavirus Infection |
| disease | MESH | infections |
| disease | IDO | host |
| pathway | REACTOME | Immune System |
| disease | VO | Viruses |
| disease | VO | Severe acute respiratory syndrome coronavirus 2 |
| disease | MESH | leukemia |
| disease | IDO | pathogen |
| disease | MESH | PRRs |
| drug | DRUGBANK | Fenamole |
| disease | IDO | production |
| disease | MESH | common cold |
| disease | MESH | lung injuries |
| disease | IDO | infection |
| pathway | KEGG | Viral replication |
| drug | DRUGBANK | Coenzyme M |
| disease | VO | effective |
| disease | VO | Betacoronavirus |
| drug | DRUGBANK | Angiotensin II |
| disease | IDO | cell |
| drug | DRUGBANK | Serine |
| pathway | KEGG | Endocytosis |
| drug | DRUGBANK | Sulfate ion |
| disease | MESH | shock |
| disease | IDO | replication |
| disease | IDO | process |
| disease | VO | efficiency |
| drug | DRUGBANK | L-Leucine |
| disease | IDO | immune response |
| drug | DRUGBANK | ATP |
| disease | MESH | viral infections |
| disease | VO | time |
| drug | DRUGBANK | Tretinoin |
| disease | VO | gene |
| pathway | KEGG | Apoptosis |
| drug | DRUGBANK | N-acetylsulfanilyl chloride |
| drug | DRUGBANK | Zinc |
| disease | IDO | site |
| drug | DRUGBANK | L-Arginine |
| disease | MESH | COVID-19 |