Publication date: Jun 17, 2024

Medical treatment of coronavirus 19 disease (COVID-19) is a therapeutic challenge. The available data strongly suggest that calcifediol treatment may reduce the severity of COVID-19, and corticosteroids are the treatment of choice worldwide for severe COVID-19. Both have a very similar action profile, and their combined use in patients may modify the contribution of each administered compound. To evaluate how treatment with calcifediol and/or corticosteroids in medical practice modified the need for ICU admission, death, or poor prognosis of patients hospitalized with COVID-19 during the first outbreaks. A retrospective observational cohort study of patients admitted for COVID-19 to the Pneumology Unit of the Hospital Universitario Reina SofcEDa (CcF3rdoba, Spain). Patients were treated with calcifediol or/and corticosteroids with the best available therapy and standard care, according to clinical practice guidelines. Admission to the intensive care unit (ICU) or death during hospitalization and poor prognosis. Seven hundred and twenty-eight patients were included. According to the treatment received, they were included in four groups: calcifediol (n = 68), glucocorticoids (n = 112), both (n = 510), or neither (n = 38). Of the 578 patients treated with calcifediol, 88 were admitted to the ICU (15%), while of the 150 not treated with calcifediol, 39 required ICU admission (26%) (p < 0. 01). Among the patients taking calcifediol without glucocorticoids, only 4 of 68 (5. 8%) required ICU admission, compared to 84 of 510 (16. 5%) treated with both (p = 0. 022). Of the 595 patients who had a good prognosis, 568 (82. 01%) had received treatment with calcifediol versus the 133 patients with a poor prognosis, of whom 90 (67. 66%) had received calcifediol (p < 0. 001). This difference was not found for corticosteroids. The treatment of choice for hospitalized patients with moderate or mild COVID-19 could be calcifediol, not administering corticosteroids, until the natural history of the disease reaches a stage of hyperinflammation.

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