Publication date: Jul 04, 2024
Background: Whilst SARS-CoV-2 infection has become endemic, COVID-19 related hospitalization and mortality are still considerably high. Both anti-viral and immune modulating therapies against COVID-19 are available, but they must be initiated early after infection and given only to patients of need. Currently, patients demographics and clinical pre-conditions factors are used to determine treatment eligibility. However, the latter do not provide accurate prediction and there are no useful biomarkers for early accurate prediction of COVID-19 related hospitalization risk and disease progression. Methods: Non-vaccinated patients (N=185) were recruited early after the first positive SARS-CoV-2 test. Biochemistry, hematology and 8 serum cytokine levels were longitudinally measured within the first month. Findings: Early levels of LDH, IL-6 or CRP each alone or their combinations, were identified as accurate predictors for the risk of hospitalization (sensitivity=93.6-100%, specificity=93.4-96.7%, p
| Concepts | Keywords |
|---|---|
| Biochemistry | Accurate |
| Hematology | Augsburg |
| High | Cov |
| July | Covid |
| Early | |
| Environmental | |
| Germany | |
| Hospitalization | |
| Infection | |
| Munich | |
| Paris | |
| Preprint | |
| Related | |
| Risk | |
| Sars |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | infection |
| disease | MESH | disease progression |
| disease | VO | vaccinated |
| drug | DRUGBANK | Diethylstilbestrol |
| disease | MESH | Infectious Diseases |
| disease | MESH | Allergy |