Publication date: Jul 11, 2024

To evaluate background incidence rates of 59 health outcomes of interest (HOI) in a diverse population, including important subpopulations, during the pre-COVID-19 era (1 January 2017-31 December 2019) and the COVID-19 era (1 March 2020-31 December 2020), before the introduction of COVID-19 vaccines. Observational retrospective cohort study. Annual incidence rates and 95% confidence intervals (CIs) of HOIs were estimated for each population of interest, stratified by: age, sex, age and sex and seasonality. Optum’s de-identified Clinformatics Data Mart Database (CDM). Individuals from the US general population and four subgroups of interest: influenza-vaccinated, paediatric (

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