Publication date: Jul 12, 2024
To evaluate the effect of COVID-19 during the first trimester on the rate of first- and second-trimester miscarriages. Secondary aims include the effect on stillbirths and the correlation between symptom severity and pregnancy outcomes. A retrospective matched case-control population-based study extracted data from electronic medical records of a nationwide database of the second largest healthcare organization that provides medical services to over 2 000 000 patients in Israel. Pregnancy outcomes in COVID-19-positive pregnant patients in 2020 were compared with an age- and gestational-week-matched 1:2 case-control cohort of pre-pandemic pregnant patients that received medical care in 2019. Of 68 485 pregnant women treated in 2020, 2333 were COVID-19-positive during pregnancy: 215 during the first trimester, 791 during the second trimester, and 1327 during the third trimester. We compared these data with the control cohort of 4580 pre-pandemic pregnant patients. The rate of spontaneous miscarriage was significantly higher 146/2187 (6. 3%) in COVID-19-positive patients versus 214/4580 (4. 7%), (P
| Concepts | Keywords |
|---|---|
| Healthcare | COVID‐19 infection |
| Pandemic | miscarriage |
| Pregnancy | pregnancy |
| SARS‐CoV‐2 | |
| trimester |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | MESH | miscarriages |
| disease | VO | population |
| disease | MESH | stillbirths |
| disease | IDO | symptom |
| disease | MESH | pregnancy outcomes |
| disease | VO | organization |
| disease | VO | pregnant women |
| disease | MESH | Long Covid |