The relationship between Nuclear Factor-Kappa B and Inhibitor-Kappa B parameters with clinical course in COVID-19 patients.

The relationship between Nuclear Factor-Kappa B and Inhibitor-Kappa B parameters with clinical course in COVID-19 patients.

Publication date: Jul 15, 2024

We aimed to investigate the serum Nuclear Factor Kappa B (NF-_705B) p105, NF-_705B p65 and Inhibitor Kappa B Alpha (I_705Bα) levels in patients with mild/moderate Coronavirus Disease 2019 (COVID-19) and their association with the course of the disease. Blood was drawn from 35 COVID-19 patients who applied to the Department of Emergency Medicine of Istanbul University-Cerrahpasa at the time of diagnosis and from 35 healthy individuals. The patients were evaluated to have mild/moderate degree of disease according to National Early Warning Score 2 (NEWS2) scoring and computed tomography (CT) findings. The markers were studied in the obtained serum samples, using enzyme-linked immunoassay (ELISA). Receiver Operating Characteristic (ROC) analysis was performed. Statistical significance was evaluated to be p 

Concepts Keywords
Coronavirus Adult
Ct Aged
Genes Biomarkers
Mild Biomarkers
News2 C-Reactive Protein
C-Reactive Protein
COVID-19
COVID-19
Female
Ferritins
Ferritins
fibrin fragment D
Humans
IκBα
Male
Middle Aged
NF-kappa B
NF-kappa B
NF-KappaB Inhibitor alpha
NF-KappaB Inhibitor alpha
NF-κB
NFKBIA protein, human
Oxygen (O2) requirement
RELA protein, human
ROC Curve
SARS-CoV-2
Transcription Factor RelA
Transcription Factor RelA

Semantics

Type Source Name
disease MESH clinical course
disease MESH COVID-19
disease IDO blood
disease MESH Emergency
disease VO time
drug DRUGBANK Saquinavir
drug DRUGBANK Protein C
drug DRUGBANK Fibrinogen Human
drug DRUGBANK Oxygen

Original Article

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