Publication date: Jul 19, 2024
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular changes in the host following infection is still lacking. Proteomic analysis of COVID-19 infected patients can reveal valuable data about the events and mechanisms related to the initial, progression, and terminal stages of the disease. This information can lead to better prevention, treatment, and convalescence strategies. In this review, we discuss blood proteomic studies based on mass spectrometry in COVID-19 patients. The analysis focuses on various blood components including plasma, platelets, serum, red blood cells, and peripheral blood mononuclear cells. Scientific papers published since 2022 are covered, with approaches categorized based on whether they use in-gel, in-solution, or on-beads/on-filter digestion modes. Additionally, candidate protein biomarkers related to COVID-19 are surveyed and discussed.
| Concepts | Keywords |
|---|---|
| Biomarkers | Biomarker |
| Blood | Blood proteomics |
| Covid | COVID-19 |
| Platelets | Mass spectrometry |
| Valuable | Sample preparation |
| SARS-CoV-2 | |
| Virus infection |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | blood |
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | IDO | host |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | convalescence |
| pathway | REACTOME | Digestion |
| disease | MESH | Virus infection |