Role of Natural Products against the Spread of SARS-CoV-2 by Inhibition of ACE-2 Receptor: A Review.

Role of Natural Products against the Spread of SARS-CoV-2 by Inhibition of ACE-2 Receptor: A Review.

Publication date: Jul 22, 2024

A unique extreme acute breathing syndrome emerged in China and spread rapidly globally due to a newly diagnosed human coronavirus and declared a pandemic. COVID-19 was formally named by WHO, and the Global Committee on Taxonomy referred to it as extreme Acute respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Currently there is no efficient method to control the extent of SARS-CoV-2 other than social distancing and hygiene activities. This study aims to present a simple medicinal strategy for combating fatal viral diseases like COVID-19 with minimum effort and intervention. Different Ayurveda medicines (Curcuma longa, green tea, andPiper nigrum) inhibit virus entrance and pathogen transmission while also enhancing immunity. Piperine (1-piperoylpiperidine), as well as curcumin, combine to create an intermolecular complex (ππ) that improves curcumin bioavailability by inhibiting glucuronidation of curcumin in the liver. The receptor-binding domains of the S-protein and also the angiotensin-converting enzyme 2 receptor of the recipient organism are directly occupied by curcumin and catechin, respectively, thereby preventing viruses from entering the cell. As a result, the infection will be tolerated by the animal host.

Concepts Keywords
China 1-piperoylpiperidine
Coronavirus 2019-nCoV
Efficient ACE-2
Global catechin
Tea curcumin
inhibitors
TMPRSS2.

Semantics

Type Source Name
disease MESH syndrome
disease MESH COVID-19
disease VO efficient
disease MESH viral diseases
disease IDO intervention
drug DRUGBANK Green tea leaf
disease IDO pathogen
drug DRUGBANK Piperine
drug DRUGBANK Curcumin
pathway REACTOME Glucuronidation
drug DRUGBANK Angiotensin II
disease IDO organism
drug DRUGBANK Cianidanol
disease VO Viruses
disease IDO cell
disease MESH infection
disease IDO host

Original Article

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