Publication date: Jul 22, 2024
A unique extreme acute breathing syndrome emerged in China and spread rapidly globally due to a newly diagnosed human coronavirus and declared a pandemic. COVID-19 was formally named by WHO, and the Global Committee on Taxonomy referred to it as extreme Acute respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Currently there is no efficient method to control the extent of SARS-CoV-2 other than social distancing and hygiene activities. This study aims to present a simple medicinal strategy for combating fatal viral diseases like COVID-19 with minimum effort and intervention. Different Ayurveda medicines (Curcuma longa, green tea, andPiper nigrum) inhibit virus entrance and pathogen transmission while also enhancing immunity. Piperine (1-piperoylpiperidine), as well as curcumin, combine to create an intermolecular complex (ππ) that improves curcumin bioavailability by inhibiting glucuronidation of curcumin in the liver. The receptor-binding domains of the S-protein and also the angiotensin-converting enzyme 2 receptor of the recipient organism are directly occupied by curcumin and catechin, respectively, thereby preventing viruses from entering the cell. As a result, the infection will be tolerated by the animal host.
Concepts | Keywords |
---|---|
China | 1-piperoylpiperidine |
Coronavirus | 2019-nCoV |
Efficient | ACE-2 |
Global | catechin |
Tea | curcumin |
inhibitors | |
TMPRSS2. |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | syndrome |
disease | MESH | COVID-19 |
disease | VO | efficient |
disease | MESH | viral diseases |
disease | IDO | intervention |
drug | DRUGBANK | Green tea leaf |
disease | IDO | pathogen |
drug | DRUGBANK | Piperine |
drug | DRUGBANK | Curcumin |
pathway | REACTOME | Glucuronidation |
drug | DRUGBANK | Angiotensin II |
disease | IDO | organism |
drug | DRUGBANK | Cianidanol |
disease | VO | Viruses |
disease | IDO | cell |
disease | MESH | infection |
disease | IDO | host |