Publication date: Jul 20, 2024
Healthcare workers (HCWs) are recommended to receive at least three spike-antigen exposures to generate basic immunity and to mediate herd protection of vulnerable patients. So far, less attention has been put on the cellular immune response induced by homologous (three BTN162b2mRNA doses) or heterologous (mRNA-1273 as third dose building on two BTN162bmRNA doses) and the immunological impact of breakthrough infections (BTIs). Therefore, in 356 vaccinated HCWs with or without BTIs the Anti-SARS-CoV-2-Spike-IgG concentrations and avidities and B- and T-cell-reactivity against SARS-CoV-2-Spike-S1- and Nucleocapsid-antigens were assessed with Interferon-gamma-ELISpot and by flow-cytometry. HCWs who had hybrid immunity due to BTIs exhibited strong T-cell-reactivity against the Spike-S1-antigen. A lasso regression model revealed a significant reduction in T-cell immune responses among smokers (p
Open Access PDF
| Concepts | Keywords |
|---|---|
| Antigen | Anti-SARS-CoV-2-Spike IgG |
| Btn162b2mrna | COVID-19 vaccination |
| Covid | Healthcare workers |
| Healthcare | T-cellular immunity |
| Herd | T-SPOT.COVID |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | VO | vaccination |
| disease | VO | dose |
| disease | MESH | breakthrough infections |
| disease | VO | vaccinated |
| disease | IDO | cell |