Establishment of a multisite umbrella cohort study protocol to describe the epidemiology and aetiologies of acute undifferentiated febrile illness in Latin America.

Publication date: Jul 22, 2024

Acute undifferentiated febrile illnesses (AUFIs) impose a large burden in the tropics. Understanding of AUFI’s epidemiology is limited. Insufficient diagnostic capacity hinders the detection of outbreaks. The lack of interconnection in healthcare systems hinders timely response. We describe a protocol to study the epidemiology and aetiologies of AUFI and pathogen discovery in strategic areas of Latin America (LA). Global Infectious Diseases Network investigators comprising institutions in Colombia, Dominican Republic, McE9xico, PercFA and the USA, developed a common cohort study protocol. The primary objective is to determine the aetiologies of AUFI at healthcare facilities in high-risk areas. Data collection and laboratory testing for viral, bacterial and parasitic agents are performed in rural and urban healthcare facilities and partner laboratories. Centralised laboratory and data management cores deploy diagnostic tests and data management tools. Subjects >6 years with fever for

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Concepts	Keywords
Bacterial	Acute Disease
Colombia	Cohort Studies
Epidemiology	COVID-19
Fever	epidemiology
Global	Fever
	Humans
	Latin America
	neglected diseases
	public health
	Research Design
	tropical medicine
	virology

Semantics

Type	Source	Name
disease	VO	protocol
disease	VO	LACK
disease	IDO	pathogen
disease	MESH	Infectious Diseases
disease	VO	USA
disease	MESH	infection
disease	IDO	blood
disease	MESH	Malaria
pathway	KEGG	Malaria
disease	MESH	dengue
disease	MESH	Venezuelan equine encephalitis
disease	MESH	Leptospira infection
disease	MESH	spotted fever
disease	MESH	rickettsioses
disease	IDO	process
disease	IDO	site
disease	VO	storage
drug	DRUGBANK	Trestolone
disease	VO	device
disease	IDO	quality
drug	DRUGBANK	Coenzyme M
disease	MESH	blood clots
disease	VO	Viruses
drug	DRUGBANK	Spinosad
disease	IDO	country
drug	DRUGBANK	Mitomycin
pathway	REACTOME	Translation
disease	VO	Yellow fever virus
disease	MESH	yellow fever
disease	MESH	Zoonotic diseases
drug	DRUGBANK	Palm oil
disease	MESH	Etiology
disease	MESH	scrub typhus
disease	MESH	Acute Disease
disease	MESH	COVID-19
disease	MESH	neglected diseases

Original Article

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