Publication date: Jul 25, 2024
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies.
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| disease | IDO | cell |
| disease | VO | population |
| disease | VO | vaccination |
| disease | MESH | infection |
| drug | DRUGBANK | Tetanus Immune Globulin |
| disease | IDO | assay |
| disease | VO | LACK |
| disease | VO | Glycoprotein |