Publication date: Jul 25, 2024
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119P2RY12CD68Iba1HLA-DRCD11cSCAMP2 microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8 parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.
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| Concepts | Keywords |
|---|---|
| Covid | COVID-19 |
| Neurological | Imaging mass cytometry |
| Pathogenesis | Long-COVID |
| Survivors | Microglia |
| Neuro-long-COVID-19 | |
| PACS | |
| PCC | |
| Post-acute COVID syndrome | |
| Post-COVID condition | |
| SARS-CoV-2 |
Original Article
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