Publication date: Jul 24, 2024

Endothelial Activation and Stress Index (EASIX) reflects endothelial dysfunction or damage. Because endothelial dysfunction is one of the key mechanisms, a few studies have shown the clinical usefulness of original and age-adjusted EASIX (age-EASIX) in patients with coronavirus disease-19 (COVID-19). We aimed to evaluate the clinical utility of age-EASIX in predicting ICU mortality in critically ill patients with COVID-19 in South Korea. Secondary analysis was performed using clinical data retrospectively collected from 22 nationwide hospitals in South Korea between January 1, 2020, and August 31, 2021. Patients were at least 19 years old and admitted to the ICU for severe COVID-19, demanding at least high-flow nasal cannula oxygen therapy. EASIX [lactate dehydrogenase (U/L) cD7 creatinine (mg/dl) /platelet count (109 cells/L)] and age-EASIX (EASIX cD7 age) were calculated and log2-transformed. The mean age of 908 critically ill patients with COVID-19 was 67. 4 years with 59. 7% male sex. The mean log2 age-EASIX was 7. 38 +/- 1. 45. Non-survivors (n=222, 24. 4%) in the ICU had a significantly higher log2 age-EASIX than of survivors (8. 2 +/- 1. 52 vs 7. 1 +/- 1. 32, P

Semantics

Original Article