Publication date: Jul 25, 2024
COVID-19 increases the risk of neurological and gastrointestinal sequelae, but it is unclear if it does so more than other infections. Using a multicenter record network, we matched 649,478 COVID-19 patients to negative controls (NCs) and patients infected with influenza, human herpesvirusses, and lyme’s disease (LD) to compare new-onset gastrointestinal (GISx), autonomic (ANSx), sensory (SNSx), and motor (MNSx) symptoms 3-12 months after infection. ANSx showed significant increases compared to NCs (odds ratio (OR) 1.34; confidence interval (CI) 1.31-1.36) and most other investigated infections (LD, influenza, infectious mononucleosis, and herpes zoster; OR 1.40, 1.13, 1.11, and 1.05, respectively). SNSx (OR 1.35; CI 1.31-1.39), MNSx (OR 1.32; CI 1.28-1.36) and GISx (OR 1.36; CI 1.33-1.38) were increased but varied more compared with other infections. COVID-19 vaccination reduced the risk of GISx, ANSx, and SNSx. Sequelae frequently ascribed to COVID-19 may manifest with similar or higher frequency after other infections, except ANSx.
| Concepts | Keywords |
|---|---|
| Arizona | Ansx |
| Chickenpox | Cov |
| Herpesvirusses | Covid |
| Increased | Gastrointestinal |
| Gisx | |
| Infections | |
| Influenza | |
| Medrxiv | |
| Ncs | |
| Neurological | |
| Preprint | |
| Sars | |
| Sequelae | |
| Snsx | |
| Symptoms |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | sequelae |
| disease | MESH | influenza |
| disease | MESH | infections |
| disease | VO | vaccination |
| disease | MESH | COVID-19 |
| disease | IDO | infection |
| disease | MESH | infectious mononucleosis |
| disease | MESH | herpes zoster |
| disease | VO | frequency |
| disease | MESH | Gastrointestinal Disorders |
| disease | VO | USA |
| disease | MESH | ‘Long COVID |
| disease | MESH | gastro esophageal reflux disease |
| disease | MESH | cognitive dysfunction |
| disease | MESH | neuralgia |
| disease | MESH | autoimmunity |
| disease | MESH | dysbiosis |
| disease | MESH | abnormalities |
| disease | MESH | polyneuropathies |
| disease | MESH | myopathies |
| disease | MESH | bacterial infection |
| disease | VO | study design |
| disease | MESH | Varicella |
| disease | IDO | symptom |
| disease | VO | population |
| drug | DRUGBANK | Methionine |
| disease | MESH | infectious diseases |