Publication date: Aug 01, 2024

The efficacy of three antimicrobials was evaluated against two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogates – bovine coronavirus (BCoV) and human coronavirus (HCoV) OC43 – on hard and soft nonporous materials. Three antimicrobials with three different active ingredients (chlorine, hydrogen peroxide, and quaternary ammonium compound + alcohol) were studied. Initially, a neutralization method was optimized for each antimicrobial. Then, we determined their efficacy against BCoV and HCoV OC43 in both suspension and on surfaces made with polyethylene terephthalate (PET) plastic and vinyl upholstery fabric. All tests were conducted under ambient environmental conditions with a soil load of 5% fetal bovine serum. After a 2-min exposure, all three antimicrobials achieved a >3. 0 log reduction in viral titers in suspension. All three also reduced virus infectivity on both surface materials below the detection limit (0. 6 log TCID/carrier). Treatments in which the reduction in virus titer was

Semantics

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