Publication date: Jul 18, 2024
Post-acute COVID-19 vaccination syndrome (PACVS) is a chronic disease triggered by SARS-CoV-2 vaccination (estimated prevalence 0. 02%). PACVS is discriminated from the normal post-vaccination state by altered receptor antibodies, most notably angiotensin II type 1 and alpha-2B adrenergic receptor antibodies. Here, we investigate the clinical phenotype using a study registry encompassing 191 PACVS-affected persons (159 females/32 males; median ages: 39/42 years). Unbiased clustering (modified Jaccard index) of reported symptoms revealed a prevalent cross-cohort symptomatology of malaise and chronic fatigue (>80% of cases). Overlapping clusters of (i) peripheral nerve dysfunction, dysesthesia, motor weakness, pain, and vasomotor dysfunction; (ii) cardiovascular impairment; and (iii) cognitive impairment, headache, and visual and acoustic dysfunctions were also frequently represented. Notable abnormalities of standard serum markers encompassing increased interleukins 6 and 8 (>80%), low free tri-iodine thyroxine (>80%), IgG subclass imbalances (>50%), impaired iron storage (>50%), and increased soluble neurofilament light chains (>30%) were not associated with specific symptoms. Based on these data, 131/191 participants fit myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and simultaneously also several other established dysautonomia syndromes. Furthermore, 31/191 participants fit none of these syndromes. In conclusion, PACVS could either be an outlier of ME/CFS or a dysautonomia syndrome sui generis.
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| Concepts | Keywords |
|---|---|
| Acoustic | cognitive impairment |
| Basel | interleukin-6 |
| Outlier | interleukin-8 |
| Thyroxine | malaise/chronic fatigue |
| Vaccination | PACVS |
| peripheral nerve dysfunction |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | VO | vaccination |
| disease | MESH | Syndrome |
| disease | MESH | chronic disease |
| drug | DRUGBANK | Angiotensin II |
| disease | MESH | dysesthesia |
| disease | MESH | cognitive impairment |
| disease | MESH | abnormalities |
| drug | DRUGBANK | Iodine |
| drug | DRUGBANK | Iron |
| disease | VO | storage |
| disease | MESH | myalgic encephalomyelitis |
| disease | MESH | dysautonomia |
| disease | MESH | Infection |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | sequelae |
| disease | MESH | etiology |
| disease | MESH | postural tachycardia syndrome |
| disease | MESH | fibromyalgia |
| disease | MESH | chronic pain |
| disease | MESH | small fiber neuropathy |
| disease | MESH | long COVID |
| disease | IDO | blood |
| disease | IDO | host |
| disease | VO | organ |
| disease | VO | vein |
| disease | VO | USA |