Publication date: Aug 25, 2024
Several studies found an association between the risk of death for COVID-19 patients and hospital overload during the first pandemic wave. We studied this association across the French departments using 82,467 serological samples and a hierarchical Bayesian model. In high-incidence areas, we hypothesized that hospital overload would increase infection fatality rate (IFR) without increasing infection hospitalization rate (IHR). We found that increasing departmental incidence from 3% to 9% rose IFR from 0.42% to 1.14%, and IHR from 1.66% to 3.61%. An increase in incidence from 6% to 12% in people under 60 was associated with an increase in the proportion of people over 60 among those infected, from 11.6% to 17.4%. Higher incidence did increase the risk of death for infected persons, probably due to an older infected population in high-incidence areas rather than hospital overload.
| Concepts | Keywords |
|---|---|
| Hospitalizations331 | Covid |
| July | Departmental |
| Organ | France |
| Pandemic | Hospital |
| Wealthier | Ifr |
| Ihr | |
| Incidence | |
| Infected | |
| Infection | |
| Medrxiv | |
| Overload | |
| Paris | |
| Population | |
| Preprint | |
| Proportion |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | death |
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | IDO | infected population |
| drug | DRUGBANK | Cycloserine |
| drug | DRUGBANK | Diethylstilbestrol |
| disease | VO | effective |
| drug | DRUGBANK | Etoperidone |
| disease | VO | population |
| disease | MESH | uncertainty |
| disease | IDO | object |
| disease | MESH | obesity |
| disease | IDO | blood |
| drug | DRUGBANK | Trestolone |
| disease | IDO | country |
| disease | IDO | immunosuppression |
| disease | IDO | history |
| disease | VO | age |
| drug | DRUGBANK | Aspartame |
| disease | IDO | algorithm |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | Cancer |
| disease | VO | publication |
| disease | MESH | Acute Respiratory Distress Syndrome |
| disease | MESH | Tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | VO | time |
| disease | VO | vaccine |
| disease | VO | organ |
| disease | MESH | critically ill |
| disease | MESH | nutritional status |