Relationship Between IL-10 Single Nucleotide Polymorphisms (rs1800871, rs1800872, and rs1800896) and the Severity of COVID-19.

Publication date: Sep 10, 2024

Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose levels are elevated in patients with severe COVID-19. IL-10 polymorphisms may play a role in increasing IL-10 levels and the severity of COVID-19. This study aimed to investigate the relationship between IL-10 single nucleotide polymorphisms (SNPs) (rs1800896 [-1082 C G], and rs1800872 [-592 T > G]) and the severity of COVID-19 in patients from Kermanshah Province, Iran. Methods: A total of 150 patients with mild COVID-19 (84 men and 66 women aged 40. 1 +/- 12. 44 years) and 143 patients with severe COVID-19 (76 men and 67 women aged 61. 04 +/- 15. 65 years) participated in this study. Blood samples were collected from the patients, DNA was extracted, and the genotype of each SNPs was determined using the polymerase chain reaction-restriction fragment length polymorphism method. Result: The results of this study did not show a significant relationship between the genotypes of the three studied SNPs and the severity of COVID-19 (p > 0. 05). Conclusion: According to our findings, these SNPs were not associated with COVID-19 severity in patients in Kermanshah.

Concepts Keywords
Biomarkers COVID-19
Inflammatory interleukin-10
Kermanshah single nucleotide polymorphism
Rs1800896
Women

Semantics

Type Source Name
drug DRUGBANK Interleukin-10
disease MESH COVID-19
disease IDO role
disease IDO blood
disease MESH restriction fragment length polymorphism
disease MESH Long Covid

Original Article

(Visited 1 times, 1 visits today)