Publication date: Sep 10, 2024
Limited evidence exists regarding the link between coronavirus disease 2019 (COVID-19) and pneumothorax. Therefore, we aimed to evaluate the occurrence rate of pneumothorax in hospitalized patients with COVID-19 and compare the risk of pneumothorax between patients with COVID-19 and influenza. This retrospective cohort study used patient data from the National Health Insurance Service of South Korea. Patients diagnosed with COVID-19 (December 2019 to December 2021) and influenza (January 2019 to December 2021) who required hospitalization and respiratory support were included. We identified 46,460 patients with COVID-19 and 6,117 with influenza. The occurrence rate of pneumothorax was 0. 74% in patients with COVID-19. In an inverse probability of treatment weighting matched cohort, the Cox proportional hazards regression model showed that COVID-19 was not associated with an increased risk of pneumothorax compared to influenza (hazard ratio, 1. 22; 95% confidence interval, 0. 75-1. 99). However, the risk of pneumothorax associated with COVID-19 compared to influenza was significantly higher in patients without chronic lung disease than in those with (P for heterogeneity = 0. 037). In conclusion, COVID-19, compared with influenza, is not associated with an increased risk of pneumothorax; however, it is associated with an increased risk in patients without chronic lung disease.
Open Access PDF
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | pneumothorax |
disease | MESH | COVID-19 |
disease | MESH | influenza |
disease | MESH | lung disease |
drug | DRUGBANK | Coenzyme M |
disease | MESH | Pneumonia |
drug | DRUGBANK | Medical air |
disease | MESH | COPD |
disease | MESH | emphysema |
disease | MESH | infections |
disease | IDO | susceptibility |
drug | DRUGBANK | Oxygen |
drug | DRUGBANK | Isoxaflutole |
disease | MESH | comorbidity |
drug | DRUGBANK | Trestolone |
pathway | KEGG | Coronavirus disease |
disease | MESH | Hypertension |
disease | MESH | Myocardial infarction |
disease | MESH | Congestive heart failure |