Adverse cardiovascular and kidney outcomes in people with SARS-CoV-2 treated with SGLT2 inhibitors.

Publication date: Sep 11, 2024

Whether use of SGLT2 inhibitors reduces the risk of cardiovascular and kidney events in people who contracted SARS-CoV-2 infection is not clear. We used the healthcare databases of the United States Department of Veterans Affairs to build a cohort of 107,776 participants on antihyperglycemic therapy and had SARS-CoV-2 infection between March 01, 2020 and June 10, 2023. Within them, 11,588 used SGLT2 inhibitors and 96,188 used other antihyperglycemics. We examined the risks of major adverse cardiovascular events (MACE)-a composite of death, myocardial infarction and stroke, and major adverse kidney events (MAKE)-a composite of death, eGFR decline > 50%, and end stage kidney disease after balancing baseline characteristics between groups through inverse probability weighting. Survival analyses were conducted to generate hazard ratio (HR) and absolute risk reduction per 100 person-years (ARR). Over a median follow up of 1. 57 (IQR: 1. 05-2. 49) years, compared to the control group, SGLT2 inhibitors use is associated with reduced risk of MACE (HR 0. 82 (0. 77, 0. 88), ARR 1. 73 (1. 21, 2. 25)) and reduced risk of MAKE (HR 0. 75 (0. 71, 0. 80), ARR 2. 62 (2. 13, 3. 11)). Compared to the control group, SGLT2 inhibitors use is associated with reduced risk of the secondary outcomes of hospitalization (HR 0. 94 (0. 90, 0. 98), ARR 1. 06 (1. 36, 1. 76)), anemia (HR 0. 71 (0. 65, 0. 76), ARR 2. 43 (1. 95, 2. 90)), and acute kidney injury (HR 0. 84 (0. 79, 0. 89), ARR 1. 86 (1. 29, 2. 42)). Among people with SARS-CoV-2 infection on antihyperglycemic therapy, compared to those on other antihyperglycemics, those on SGLT2 inhibitors have less risk of adverse cardiovascular and kidney outcomes.

Concepts Keywords
Antihyperglycemics Adverse
Hospitalization Arr
Kidney Cardiovascular
Veterans Compared
Cov
Events
Hr
Infection
Inhibitors
Kidney
Outcomes
Reduced
Risk
Sars
Sglt2

Semantics

Type Source Name
disease MESH SARS-CoV-2 infection
pathway REACTOME SARS-CoV-2 Infection
disease MESH death
disease MESH myocardial infarction
disease MESH stroke
disease MESH end stage kidney disease
disease MESH anemia
disease MESH acute kidney injury

Original Article

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