Publication date: Sep 17, 2024
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vital for COVID-19 research. Methods: We investigated the proteomic and genomic profile of COVID-19-positive patients (n = 400 for proteomics, n = 483 for genomics), focusing on differential regulation between hospitalised and non-hospitalised COVID-19 patients. Signatures had their predictive capabilities tested using independent machine learning models such as Support Vector Machine (SVM), Random Forest (RF) and Logistic Regression (LR). Results: This study has identified 224 differentially expressed proteins involved in various inflammatory and immunological pathways in hospitalised COVID-19 patients compared to non-hospitalised COVID-19 patients. LGALS9 (p-value < 0. 001), LAMP3 (p-value < 0. 001), PRSS8 (p-value < 0. 001) and AGRN (p-value < 0. 001) were identified as the most statistically significant proteins. Several hundred rsIDs were queried across the top 10 significant signatures, identifying three significant SNPs on the FSTL3 gene showing a correlation with hospitalisation status. Conclusions: Our study has not only identified key signatures of COVID-19 patients with worsened health but has also demonstrated their predictive capabilities as potential biomarkers, which suggests a staple role in the worsened health effects caused by COVID-19.
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Semantics
Type | Source | Name |
---|---|---|
disease | MESH | COVID-19 |
disease | IDO | role |
disease | MESH | infection |
disease | IDO | pathogen |
disease | MESH | cytokine storm |
disease | MESH | sore throats |
drug | DRUGBANK | Coenzyme M |
disease | MESH | acute respiratory distress syndrome |
disease | MESH | septic shock |
disease | MESH | morbidities |
drug | DRUGBANK | Aspartame |
disease | IDO | blood |
drug | DRUGBANK | Edetic Acid |
disease | MESH | inflammation |
disease | IDO | assay |
disease | IDO | reagent |
disease | IDO | protein |
drug | DRUGBANK | Pidolic Acid |
drug | DRUGBANK | Pentaerythritol tetranitrate |
disease | MESH | Confusion |
drug | DRUGBANK | Saquinavir |