Publication date: Sep 17, 2024
To estimate vaccine effectiveness(VE) against COVID-19-related hospitalization for inactivated vaccines during the Omicron BF. 7-predominant epidemic wave in Beijing, China. We recruited a cohort in Beijing on 17 and 18 December 2022, collected status of vaccination and COVID-19-related hospitalization since 1 November 2022 and prospectively followed until 9 January 2023. A Poisson regression model was used to estimate the VE. 16(1. 15%) COVID-19-related hospitalizations were reported in 1391 unvaccinated participants; 7(0. 25%) in 2765 participants with two doses, resulting in a VE of 70. 89%(95% confidence interval[CI] 26. 25 to 87. 73); 32(0. 27%) in 11,846 participants with three doses, with a VE of 65. 25%(95% CI 32. 24 to 81. 83). The VE of three doses remained above 64% at 1 year or more since the last dose. Elderly people aged ≥ 60 years had the highest hospitalization incidence(0. 66%), VE for two doses was 74. 11%(95%CI: - 18. 42 to 94. 34) and VE for three doses was 80. 98%(95%CI:52. 83 to 92. 33). We estimated that vaccination had averted 65,007(95%CI: 12,817 to 97,757) COVID-19-related hospitalizations among people aged ≥ 60 years during the BF. 7-predominant period in Beijing. Inactivated COVID-19 vaccines were effective against COVID-19-related hospitalization, especially for the elderly population who have increased risk of severe disease owing to SARS-CoV-2 infection.
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Concepts | Keywords |
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Beijing | Cohort study |
December | COVID-19 |
Hospitalization | Hospitalization |
Inactivated vaccine | |
Vaccine effectiveness |
Semantics
Type | Source | Name |
---|---|---|
disease | MESH | COVID-19 |
pathway | REACTOME | SARS-CoV-2 Infection |
disease | MESH | Long Covid |
disease | MESH | Infectious Diseases |
pathway | REACTOME | Reproduction |
drug | DRUGBANK | Coenzyme M |
disease | MESH | emergency |
disease | MESH | infection |
disease | MESH | death |
disease | IDO | virulence |
drug | DRUGBANK | Ademetionine |
drug | DRUGBANK | Methionine |
drug | DRUGBANK | Ilex paraguariensis leaf |
disease | IDO | history |
disease | IDO | assay |
disease | MESH | sore throat |
disease | MESH | ageusia |
disease | MESH | anosmia |
disease | IDO | process |
disease | IDO | host |
disease | MESH | chronic diseases |
disease | MESH | uncertainty |
drug | DRUGBANK | Trestolone |
drug | DRUGBANK | Methyl isocyanate |
disease | MESH | viral shedding |
disease | MESH | coronavirus infection |
disease | MESH | Influenza |
disease | MESH | complications |
disease | IDO | cell |