Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19.

Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19.

Publication date: Oct 18, 2024

We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

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Concepts Keywords
Alfa Association analysis
Pharmacological Disease
Pulmonary Health sciences
Randomization Respiratory medicine
Tumor

Semantics

Type Source Name
disease MESH lung diseases
disease MESH COVID-19
disease MESH asthma
pathway KEGG Asthma
disease MESH chronic obstructive pulmonary disease
drug DRUGBANK Anakinra

Original Article

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