The role of Helicobacter pylori in augmenting the severity of SARS-CoV-2 related gastrointestinal symptoms: An insight from molecular mechanism of co-infection.

The role of Helicobacter pylori in augmenting the severity of SARS-CoV-2 related gastrointestinal symptoms: An insight from molecular mechanism of co-infection.

Publication date: Sep 30, 2024

Coinfection of pathogenic bacteria and viruses is associated with multiple diseases. During the COVID-19 pandemic, the co-infection of other pathogens with SARS-CoV-2 was one of the important determinants of the severity. Although primarily a respiratory virus gastric manifestation of the SARS-CoV-2 infection was widely reported. This study highlights the possible consequences of SARS-CoV-2 -Helicobacter pylori coinfection in the gastrointestinal cells. We utilized the transfection and infection model for SARS-CoV-2 spike Delta (δ) and H. pylori respectively in colon carcinoma cell line HT-29 to develop the coinfection model to study inflammation, mitochondrial function, and cell death. The results demonstrate increased transcript levels of inflammatory markers like TLR2 (p

Concepts Keywords
Carcinoma Co-infection
Inflammatory Gastrointestine
Molecular Helicobacter pylori
Viruses Inflammation
Necroptosis
SARS-CoV-2

Semantics

Type Source Name
disease IDO role
disease MESH co-infection
disease IDO bacteria
disease MESH COVID-19 pandemic
pathway REACTOME SARS-CoV-2 Infection
disease MESH infection
disease MESH carcinoma
disease IDO cell
disease MESH inflammation
pathway KEGG Necroptosis

Original Article

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