Novel risk loci for COVID-19 hospitalization among admixed American populations.

Novel risk loci for COVID-19 hospitalization among admixed American populations.

Publication date: Oct 03, 2024

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

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Concepts Keywords
Americans Aged
Covid COVID-19
Genome COVID-19
Hospitalization Female
Polygenic Genetic Loci
genetics
Genome-Wide Association Study
genomics
GWAS
Hospitalization
Humans
Latin America
Male
Middle Aged
none
Polymorphism, Single Nucleotide
Risk Factors
SARS-CoV-2
SNP

Semantics

Type Source Name
disease MESH COVID-19
disease IDO host
disease MESH polygenic risk score

Original Article

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