Influenza B Virus Vaccine Innovation through Computational Design.

Publication date: Sep 02, 2024

As respiratory pathogens, influenza B viruses (IBVs) cause a significant socioeconomic burden each year. Vaccine and antiviral development for influenza viruses has historically viewed IBVs as a secondary concern to influenza A viruses (IAVs) due to their lack of animal reservoirs compared to IAVs. However, prior to the global spread of SARS-CoV-2, the seasonal epidemics caused by IBVs were becoming less predictable and inducing more severe disease, especially in high-risk populations. Globally, researchers have begun to recognize the need for improved prevention strategies for IBVs as a primary concern. This review discusses what is known about IBV evolutionary patterns and the effect of the spread of SARS-CoV-2 on these patterns. We also analyze recent advancements in the development of novel vaccines tested against IBVs, highlighting the promise of computational vaccine design strategies when used to target both IBVs and IAVs and explain why these novel strategies can be employed to improve the effectiveness of IBV vaccines.

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Concepts	Keywords
Innovation	computational design
Seasonal	immunogen design
Socioeconomic	influenza B viruses
Target	SARS-CoV-2
Vaccines	surveillance
	vaccines
	viral evolution

Semantics

Type	Source	Name
drug	DRUGBANK	Influenza B virus
disease	MESH	influenza
pathway	KEGG	Influenza A
drug	DRUGBANK	Etodolac
pathway	REACTOME	Influenza Infection
disease	MESH	infections
disease	MESH	point mutations
pathway	KEGG	Viral replication
drug	DRUGBANK	Coenzyme M
disease	IDO	infection
disease	MESH	COVID 19
disease	MESH	virus infections
disease	IDO	site
disease	IDO	host
drug	DRUGBANK	Fenamole
disease	MESH	breakthrough infections
disease	IDO	production
drug	DRUGBANK	Amino acids
disease	IDO	protein
disease	IDO	cell
pathway	REACTOME	Immune System
disease	MESH	morbidity
disease	IDO	replication
disease	IDO	algorithm
disease	MESH	Vaccinia
disease	MESH	lung inflammation
drug	DRUGBANK	Spinosad
disease	MESH	HIV infection
pathway	REACTOME	HIV Infection
disease	IDO	process
disease	MESH	avian influenza
disease	IDO	assay
drug	DRUGBANK	Oseltamivir
disease	IDO	nucleic acid
disease	MESH	genetic disorders
disease	MESH	Allergy
disease	MESH	Infectious Diseases
drug	DRUGBANK	Medical air
disease	IDO	susceptibility
disease	IDO	history
drug	DRUGBANK	(S)-Des-Me-Ampa
disease	MESH	mutation rates
disease	IDO	blood
disease	MESH	Pica
disease	IDO	immune response
disease	MESH	viral shedding
disease	MESH	swine influenza

Original Article

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