Publication date: Aug 23, 2024
New-onset chronic musculoskeletal (MSK) pain (>3 months duration) is a common symptom of post-COVID-19 syndrome (PCS). This study aimed to characterise new-onset chronic MSK pain in patients with PCS and its overlap with Fibromyalgia Syndrome (FMS). We enrolled patients with new-onset chronic MSK pain post-COVID-19 and assessed the nature of the pain and associated symptoms using the C19-YRS (Yorkshire Rehabilitation Scale). The FMS assessment was conducted as part of a standard clinical examination using the American College of Rheumatology (ACR) 2010 criteria: (1) Widespread Pain Index (WPI) ≥ 7 and symptoms severity (SS) score ≥ 5, or WPI between 3 and 6 and SS score ≥ 9, (2) symptoms consistent for at least 3 months, and (3) no alternative diagnosis. Of the eighteen patients (average age 49. 6 (SD 11. 8) years; BMI 31. 7 (SD 8. 6)), twelve were female. The average symptom duration was 27. 9 (SD 6. 97) months post-infection. Thirteen patients (72. 2%) met the FMS criteria, with an average WPI score of 8. 8 and an average SS score of 8. 2, indicating a high level of pain and significant quality of life impacts. These findings support the hypothesis that FMS may develop as a long-term sequela of a viral infection, underscoring the need for further research into post-viral long-term conditions.
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| Concepts | Keywords |
|---|---|
| American | chronic pain |
| Biomedicines | chronic widespread pain |
| Fibromyalgia | FM syndrome |
| Months | long COVID |
| Viral | post-acute sequela |
| post-COVID-19 condition |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Musculoskeletal Pain |
| disease | MESH | COVID-19 |
| disease | MESH | Infection |
| disease | MESH | Fibromyalgia |
| disease | MESH | Syndrome |
| disease | IDO | symptom |
| drug | DRUGBANK | Methionine |
| disease | IDO | quality |
| disease | MESH | viral infection |
| drug | DRUGBANK | LS11 |
| disease | MESH | long COVID |
| disease | MESH | chronic pain |
| disease | IDO | acute infection |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | chronic condition |
| disease | MESH | osteoarthritis |
| disease | MESH | rheumatoid arthritis |
| pathway | KEGG | Rheumatoid arthritis |
| disease | MESH | hepatitis |
| disease | MESH | infectious diseases |
| disease | IDO | site |
| disease | MESH | marital status |
| disease | MESH | breathlessness |
| disease | MESH | post traumatic stress disorder |
| disease | MESH | anxiety |
| disease | MESH | depression |
| disease | IDO | role |
| disease | MESH | arthralgia |