ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19.

ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19.

Publication date: Oct 09, 2024

SARS-CoV-2 virus infects cells by engaging with ACE2 requiring protease TMPRSS2. ACE2 is highly expressed in kidneys. Predictors for severe disease are high age and male sex. We hypothesized that ACE2 and TMPRSS2 proteins are more abundant (1) in males and with increasing age in kidney and (2) in urine and extracellular vesicles (EVs) from male patients with COVID-19 and (3) SARS-CoV-2 is present in urine and EVs during infection. Kidney cortex samples from patients subjected to cancer nephrectomy (male/female; 

Concepts Keywords
Covid Albuminuria
Kidneys Angiotensin II
Males Exosomes
Tmprss2 Hypertension
Virus Protease
SARS-CoV-2

Semantics

Type Source Name
disease MESH COVID-19
disease MESH infection
disease MESH cancer
disease MESH Albuminuria
drug DRUGBANK Angiotensin II
disease MESH Hypertension

Original Article

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