Publication date: Sep 01, 2024
Patients with post-COVID-19 condition frequently suffer from chronic dyspnoea. The causes and mechanism for dyspnoea in these patients without evidence of structural lung disease are unclear. Patients treated for COVID-19 at CharitcE9 University Hospital in Berlin received pulmonary function testing including respiratory muscle strength tests and completed health-related quality-of-life questionnaires during follow-up. Patients with post-COVID-19 condition during outpatient follow-up with fatigue and exertional intolerance (PCF) were compared to patients with post-COVID-19 condition with evidence of chronic pulmonary sequelae (post-COVID-19 restriction (PCR)) as well as to patients without post-COVID-19 condition (NCF). A total of 170 patients presented for follow-up. 36 participants met criteria for PCF, 28 for PCR and 24 for NCF. PCF patients reported dyspnoea in 63. 8%. % predicted value of respiratory muscle strength (median (IQR)) was reduced in PCF (55. 8 (41. 5-75. 9)) compared to NCF and PCR (70. 6 (66. 3-88. 9) and 76. 8 (63. 6-102. 2), respectively; p=0. 011). A pattern of reduced forced vital capacity (FVC), but normal total lung capacity (TLC), termed complex ventilatory dysfunction defined as TLC - FVC >10% predicted was observed and occurred more frequently in PCF (88. 9%) compared to NCF and PCR (29. 1% and 25. 0%, respectively; p
Open Access PDF
| Concepts | Keywords |
|---|---|
| Berlin | Chronic |
| Outpatient | Compared |
| Pcr | Complex |
| Pulmonary | Condition |
| Covid | |
| Dysfunction | |
| Dyspnoea | |
| Evidence | |
| Fatigue | |
| Follow | |
| Ncf | |
| Pcf | |
| Pcr | |
| Post | |
| Ventilatory |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | causes |
| disease | MESH | lung disease |
| disease | IDO | quality |
| disease | MESH | sequelae |
| drug | DRUGBANK | Methionine |
| disease | MESH | total lung capacity |