Meningitis after COVID-19 vaccination, a systematic review of case reports and case series.

Meningitis after COVID-19 vaccination, a systematic review of case reports and case series.

Publication date: Oct 10, 2024

Vaccination is considered as one of the most promising strategies to overcome the COVID-19 pandemic. However, it could be associated with rare but serious complications. In the present study, we aimed to review the clinical course and etiology of post COVID-19 vaccination meningitis. After a systematic search in PubMed, Scopus, and Web of Sciences online databases as well as Google Scholar, documents were screened and qualified. Then data extraction was performed and the most frequent underlying agent of meningitis was found based on the reported cases. Overall, 35 cases of post COVID-19 vaccination meningitis from 33 articles were included in the review. Among them, 12 cases had proven viral diagnosis and 23 of them were reported to be vaccine-induced. The most frequent viral pathogen among the cases was VZV. The most prevalent symptom was headache, and the most common time of appearance symptoms was one week after vaccination. Overall, our study suggested meningitis as a critical but not devastating complication of COVID-19 vaccination. Almost all patients responded well to common agents used to manage viral or vaccine-induced meningitis. It is recommended to monitor patients with a history of chickenpox after COVID-19 vaccination regarding the development of meningitis.

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Concepts Keywords
Chickenpox Adult
Frequent Aged
Google COVID-19
Meningitis COVID-19
Vaccine COVID-19 Vaccines
COVID-19 Vaccines
Female
Humans
Male
Meningitis
Meningitis
Middle Aged
Vaccination
Vaccine

Semantics

Type Source Name
disease MESH Meningitis
disease MESH COVID-19
disease MESH complications
disease MESH clinical course
disease MESH etiology
disease IDO pathogen
disease IDO symptom
disease IDO history
disease MESH chickenpox
disease MESH Infectious Diseases
pathway REACTOME Reproduction
disease IDO protein
pathway REACTOME Immune System
drug DRUGBANK Coenzyme M
disease IDO immune response
disease MESH neurological disorders
disease MESH stroke
disease MESH acute disseminated encephalomyelitis
disease MESH transverse myelitis
disease MESH syndrome
disease MESH aseptic meningitis
disease MESH myositis
disease MESH macrophagic myofasciitis
disease IDO bacteria
disease MESH Cysticercosis
disease MESH polio
disease MESH Herpes simplex
disease MESH malignancies
disease MESH arachnoiditis
disease MESH meningoencephalitis
disease IDO process
disease MESH viral meningitis
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK Trestolone
drug DRUGBANK Methionine
disease MESH dyslipidemia
disease MESH migraine
drug DRUGBANK Prednisone
drug DRUGBANK Dexamethasone
disease MESH zoster
disease MESH pleocytosis
drug DRUGBANK Acyclovir
disease MESH inflammation
disease MESH mumps
disease MESH measles
pathway KEGG Measles
disease MESH rubella
disease IDO intervention
drug DRUGBANK Immune Globulin Human
disease MESH Guillain Barre syndrome
disease MESH Cranial nerve palsies
drug DRUGBANK Tretamine
disease MESH infections
disease MESH latent infections
disease IDO cell
disease IDO production
disease IDO infection
drug DRUGBANK Acetohydroxamic acid
disease MESH Myelitis
disease MESH Phantosmia
disease MESH acute ischemic strokes
disease MESH Multiple Sclerosis
disease MESH Optic Neuritis
disease MESH bacterial meningitis
drug DRUGBANK Bismuth subgallate
disease MESH arthritis
disease MESH optic disc edema
disease MESH MEWDS
disease MESH co infection
disease MESH Herpes Zoster Ophthalmicus
disease MESH Emerging Infectious Diseases
disease MESH intracranial hypertension
disease MESH encephalitis
disease MESH myoclonus
disease MESH Sweet syndrome
disease MESH Tolosa Hunt Syndrome
drug DRUGBANK Ipilimumab
drug DRUGBANK Nivolumab
disease MESH Wasting Syndrome

Original Article

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