Publication date: Oct 23, 2024
Patients infected with SARS-CoV-2 and vaccinated against COVID-19 could develop aplastic anemia (AA). Comprehensive review and analysis were conducted through a selective literature search in PubMed, Scopus, EMBASE, and Web of Science. For this analysis, 26 studies were included, comprising 16 case reports, 7 case series, and 3 observational studies, totaling 53 patients. The causes of acquired or idiopathic AA are diverse; this review presents recent findings, including possible new etiologies such as SARS-CoV-2 infection and COVID-19 vaccines. This possible association is explored, addressing the existing gap, and aiming to improve daily medical practice. This article reviews the relationship between AA and SARS-CoV-2 infection, as well as COVID-19 vaccines, analyzing cases of de novo occurrence and relapses of AA. Although a definitive mechanistic link has not yet been established, possible underlying pathophysiological mechanisms are explored.
| Concepts | Keywords |
|---|---|
| Covid | Aplastic Anemia |
| Daily | COVID-19 |
| Pandemic | COVID-19 Vaccines |
| Science | SARS-CoV-2 |
| Vaccinated |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Aplastic Anemia |
| disease | MESH | COVID-19 pandemic |
| disease | MESH | infection |
| disease | MESH | causes |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | relapses |