Advances research in porcine enteric coronavirus therapies and antiviral drugs.

Publication date: Dec 01, 2024

The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection.

Concepts Keywords
Coronaviruses Alphacoronavirus
Efficiency Animals
Fatal Antiviral Agents
Pig Antiviral Agents
Sleepiness antiviral drugs
Coronavirus Infections
Deltacoronavirus
PDCoV
PEDV
SADS-CoV
Swine
Swine Diseases
TGEV
therapy
Transmissible gastroenteritis virus

Semantics

Type Source Name
disease MESH gastroenteritis
disease MESH syndrome
disease MESH weight loss
disease MESH sleepiness
disease MESH anorexia
disease IDO production
disease MESH infection
disease MESH Coronavirus Infections
disease MESH Swine Diseases

Original Article

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