Publication date: Nov 04, 2024
The objective of this study is to investigate the the relationships between HLA-G gene variants and sHLA-G with susceptibility to SARS-CoV-2 infection. In this case-control study, 65 Patients with COVID-19 were and 67 healthy controls were genotyped for their main functional polymorphisms namely, the 14-bp Ins/Del (rs371194629), +3003C/T (rs1707), +3010C/G (rs1710), +3027A/C (rs17179101), +3035C/T (rs17179108), +3142C/G (rs1063320), +3187A/G (rs9380142) and +3196C/G (rs1610696) in the exon 8 of the 3′ untranslated regions (3′ UTRs) using sanger sequencing method. Associations were assessed for five inheritance models (codominant, dominant, recessive, over-dominant and log-additive). Moreover, the levels of plasma soluble HLA-G (sHLA-G) were explored using ELISA method. Our results revealed that the 14-bp INS/DEL polymorphism was strongly associated with COVID-19 symptoms development for almost all tested inheritance models (p
| Concepts | Keywords |
|---|---|
| Biochem | 3’UTR polymorphisms |
| Elisa | COVID-19 genetic predisposition |
| Log | Haplotypes |
| Models | Immune checkpoint |
| Rs371194629 | Saudi Arabia |
| SHLA-G |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | IDO | susceptibility |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | Long Covid |